Reasons for Intraindividual Inconstancy of the Digoxin Saliva to Serum Concentration Ratio
نویسندگان
چکیده
منابع مشابه
Reasons for intraindividual inconstancy of the digoxin saliva to serum concentration ratio.
When a constant dose of digoxin was administered orally over several days, the digoxin concentration in saliva and erythrocytes rose faster than in serum. Thus, the saliva/serum concentration ratio was below 1.0 after a single dose and above 1.0 in the steady state. The digoxin concentration was relatively high in "unstimulated" (more or less spontaneous) saliva and decreased with stimulation o...
متن کاملAssessment of Abnormal Serum Digoxin Concentration
ABSTRACT Cardiac glycosides have been used in the management of heart failure for more than 200 years and remain the only drug currently available for Long-term ambulatory use that have positive inotropic effect. The relatively narrow therapeutic- index of cardiac glycosides renders them particularly difficult to use, and the clinician should have a detailed understanding of the actions and ph...
متن کاملQuinidine-digoxin interaction: cardiac efficacy of elevated serum digoxin concentration.
Cardioactivity due to elevated serum digoxin concentration (SDC) after quinidine (Q) and digoxin (D) was evaluated in six healthy subjects by means of measurement of systolic time intervals (STIs). Each subject randomly received basic treatments with 0.2 mg D and placebo (PL1). Randomized coadministrations with Q (1 gm/day), sparteine (SP) (0.8 gm/day), and placebo (PL2) were given for 7-day pe...
متن کاملThe influence of verapamil on serum digoxin concentration.
The effect of verapamil on the pharmacokinetics of digoxin was studied in 49 patients with chronic atrial fibrillation. A dose of 240 mg/day of verapamil was given to the patients who were receiving a stable dose of digoxin. Serum digoxin levels rose from 0.76 +/- 0.54 ng/ml (mean +/- SD) to 1.31 +/- 0.54 ng/ml during verapamil treatment (p less than 0.0005). This effect was dose-dependent, as ...
متن کاملSerum cystatin C levels to predict serum concentration of digoxin in Japanese patients
Cystatin C (Cys-C) has been recently paid great attention as a better endogenous marker of the glomerular filtration rate than creatinine (Cr). In this study, the usefulness of Cys-C was compared with Cr in terms of the estimation of the steady-state serum trough concentrations of digoxin in Japanese patients. Forty patients treated with digoxin and 56 healthy elderly subjects were participated...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Chemistry and Laboratory Medicine
سال: 1989
ISSN: 1434-6621,1437-4331
DOI: 10.1515/cclm.1989.27.9.653